| Annotated protein: | Sodium- and chloride-dependent GABA transporter 3 (GAT-3) (Sodium- and chloride-dependent GABA transporter 4) (GAT-4) (Solute carrier family 6 member 11). Gene symbol: SLC6A11. Taxonomy: Mus musculus (Mouse). Uniprot ID: P31650 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ SLC6A11 |
| Ontology domain: | Cellular Component |
| SynGO term: | synapse (GO:0045202) |
| Synapse type(s): | brain |
| Annotated paper: | Weingarten J, et al. "The proteome of the presynaptic active zone from mouse brain" Mol Cell Neurosci. 2014 Mar;59:106-18 PMID:24534009 |
| Figure(s): | Supple Table S1 |
| Annotation description: | S6A11_MOUSE was identified in the proteome of the immuno-purified presynaptic active zone from mouse brain. However, see additional literature. |
| Evidence tracking, Biological System: | Intact tissue |
| Evidence tracking, Protein Targeting: | none of the above |
| Evidence tracking, Experiment Assay: | Mass-spectrometry Biochemical fractionation (generic) |
| Annotator(s): | Daniela Dieterich (ORCID:0000-0002-9880-1214) Rainer Pielot (ORCID:0000-0002-9681-3318) Karl-Heinz Smalla (ORCID:0000-0002-0269-0311) Eckart Gundelfinger (ORCID:0000-0001-9377-7414) |
| Lab: | Leibniz Institute for Neurobiology (LIN), Institute of Pharmacology and Toxicology, Otto von Guericke University, Center for Behavioral Brain Sciences (CBBS), Magdeburg, Germany |
| Additional literature: | This study localizes GAT-3 mainly to astrocytic endfeet closely associated with GABAergic synapses. @ PMID:8815906 This study also finds GAT-3 as 0.056 % of total protein in presynaptic protein fraction (table S2). @ PMID:24876496 |
| SynGO annotation ID: | 644 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |