| Annotated protein: | Eukaryotic translation initiation factor 4E (eIF-4E) (eIF4E) (mRNA cap-binding protein) (eIF-4F 25 kDa subunit). Gene symbol: EIF4E. Taxonomy: Mus musculus (Mouse). Uniprot ID: P63073 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ EIF4E |
| Ontology domain: | Biological Process |
| SynGO term: | regulation of translation at postsynapse, modulating synaptic transmission (GO:0099578) |
| Synapse type(s): | hippocampus, glutamatergic cerebral cortex, glutamatergic striatum, glutamatergic |
| Annotated paper: | Santini E, et al. "Exaggerated translation causes synaptic and behavioural aberrations associated with autism" Nature. 2013 Jan 17;493(7432):411-5 PMID:23263185 |
| Figure(s): | Fig. 1,3 |
| Annotation description: | eIF-4E is involved in cap-dependent initation of translation (Fig. 1). Exaggerated expression of eIF-4E causes alterations in synaptic function, dendritic spine density and synaptic plasticity (Fig. 3). 8/8/2017 Pim - eIF-4E KO shown to enhance translation and shown to have enhaced mPFC, striatal and hippocampal LTD. The LTD defects are rescued by application of a translation blocker (4EGI-1). These observations together fully support the selected term. |
| Evidence tracking, Biological System: | Intact tissue |
| Evidence tracking, Protein Targeting: | Genetic transformation (eg; knockout, knockin, mutations) |
| Evidence tracking, Experiment Assay: | Confocal Whole-cell patch clamp Field recordings Western blot |
| Annotator(s): | Daniela Dieterich (ORCID:0000-0002-9880-1214) Rainer Pielot (ORCID:0000-0002-9681-3318) Karl-Heinz Smalla (ORCID:0000-0002-0269-0311) Eckart Gundelfinger (ORCID:0000-0001-9377-7414) |
| Lab: | Leibniz Institute for Neurobiology (LIN), Institute of Pharmacology and Toxicology, Otto von Guericke University, Center for Behavioral Brain Sciences (CBBS), Magdeburg, Germany |
| SynGO annotation ID: | 592 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |