| Annotated protein: | Complexin-2 (921-L) (Complexin II) (CPX II) (Synaphin-1). Gene symbol: CPLX2. Taxonomy: Mus musculus (Mouse). Uniprot ID: P84086 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ CPLX2 |
| Ontology domain: | Cellular Component |
| SynGO term: | presynapse (GO:0098793) |
| Synapse type(s): | Calyx of Held |
| Annotated paper: | Chang S, et al. "Complexin stabilizes newly primed synaptic vesicles and prevents their premature fusion at the mouse calyx of held synapse" J Neurosci. 2015 May 27;35(21):8272-90 PMID:26019341 |
| Figure(s): | Fig. 1C, Fig. 11C |
| Annotation description: | Complexin-2 presynaptic immunoreactivity is observed in the Calyx of Held synapse in the brainstem (Fig 11C). IHC was performed using an antibody (SySy, rabbit anti-Cplx-1/2) that detects Complexin-1 and -2. Complexin-1 KO mice exhibit a loss of immunoreactivity in the somata of the MNTB principal neurons (Fig 11C) indicating the specificity of the antibody for Complexin-1, however immunoreactivity in the presynaptic terminal persist at P7 indicating the presence of Complexin-2. |
| Evidence tracking, Biological System: | Intact tissue |
| Evidence tracking, Protein Targeting: | Antibody (detection) |
| Evidence tracking, Experiment Assay: | Confocal |
| Annotator(s): | Noa Lipstein (ORCID:0000-0002-0755-5899) Cordelia Imig (ORCID:0000-0001-7351-8706) Vincent O'connor (ORCID:0000-0003-3185-5709) Nils Brose (ORCID:0000-0003-0938-8534) |
| Lab: | Department of Molecular Neurobiology, Max Planck Institute of Experimental Medicine, 37075 Göttingen, Germany |
| SynGO annotation ID: | 580 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |