| Annotated protein: | Actin-binding protein WASF1 (Protein WAVE-1) (Wiskott-Aldrich syndrome protein family member 1) (WASP family protein member 1). Gene symbol: WASF1. Taxonomy: Rattus norvegicus (Rat). Uniprot ID: Q5BJU7 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ WASF1 |
| Ontology domain: | Biological Process |
| SynGO term: | dendritic transport of mitochondrion (GO:0098939) |
| Synapse type(s): | hippocampus |
| Annotated paper: | Sung JY, et al. "WAVE1 controls neuronal activity-induced mitochondrial distribution in dendritic spines" Proc Natl Acad Sci U S A. 2008 Feb 26;105(8):3112-6 PMID:18287015 |
| Figure(s): | fig 2 |
| Annotation description: | WAVE1 controls depolarization-induced trafficking of the mitochondria to dendritic spines in hippocampal neurons cotransfected with EGFP and Mito-DsRed plus control plasmid vectors (-), WAVE1 RNAi (RNAi), or WAVE1 RNAi plus RNAi-resistant WAVE1 (Rr-WAVE1). |
| Evidence tracking, Biological System: | Cultured neurons |
| Evidence tracking, Protein Targeting: | RNAi / shRNA |
| Evidence tracking, Experiment Assay: | Confocal |
| Annotator(s): | Alexandros Kanellopoulos (ORCID:0000-0002-2094-7491) Vittoria Mariano (ORCID:0000-0002-9848-0262) Achsel Tilmann (ORCID:0000-0002-1190-4481) Claudia Bagni (ORCID:0000-0002-4419-210X) |
| Lab: | Department of Fundamental Neurosciences, University of Lausanne, CH-1006 Lausanne, Switzerland; Dept Biomedicine and Prevention, University of Rome Tor Vergata, 00133 Rome, Italy |
| Additional literature: | WAVE1 controls depolarization-induced spine growth in primary hippocampal neurons cotransfected with EGFP plus control plasmid vector, WAVE1 RNAi plasmid (RNAi), or WAVE1 RNAi plus RNAi-resistant WAVE1 (Rr-WAVE1). @ PMID:18287015 |
| SynGO annotation ID: | 570 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |