| Annotated protein: | Actin-binding protein WASF3 (Protein WAVE-3) (Wiskott-Aldrich syndrome protein family member 3) (WASP family protein member 3). Gene symbol: WASF3. Taxonomy: Mus musculus (Mouse). Uniprot ID: Q8VHI6 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ WASF3 |
| Ontology domain: | Biological Process |
| SynGO term: | modification of postsynaptic actin cytoskeleton (GO:0098885) |
| Synapse type(s): | hippocampus, glutamatergic |
| Annotated paper: | Pilpel Y, et al. "Rapid WAVE dynamics in dendritic spines of cultured hippocampal neurons is mediated by actin polymerization" J Neurochem. 2005 Dec;95(5):1401-10 PMID:16190876 |
| Figure(s): | fig 3, 4, 5 |
| Annotation description: | WAVE3 over-expression decreases spine numbers in hippocampal neutrons (11-14DIV). 9/10/2017 Pim - Fig.4 WAVE3 is shown to localize to the edge of Rac-activity induced lamellipodia. - Fig.5 The F-actin content of WAVE3 transfected cells increases This shows that WAVE3 is also involved in actin related modifications. |
| Evidence tracking, Biological System: | Cultured neurons Non-neuronal tissue |
| Evidence tracking, Protein Targeting: | Over-expression |
| Evidence tracking, Experiment Assay: | Confocal |
| Annotator(s): | Alexandros Kanellopoulos (ORCID:0000-0002-2094-7491) Vittoria Mariano (ORCID:0000-0002-9848-0262) Achsel Tilmann (ORCID:0000-0002-1190-4481) Claudia Bagni (ORCID:0000-0002-4419-210X) |
| Lab: | Department of Fundamental Neurosciences, University of Lausanne, CH-1006 Lausanne, Switzerland; Dept Biomedicine and Prevention, University of Rome Tor Vergata, 00133 Rome, Italy |
| SynGO annotation ID: | 569 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |