| Annotated protein: | Actin-binding protein WASF1 (Protein WAVE-1) (Wiskott-Aldrich syndrome protein family member 1) (WASP family protein member 1). Gene symbol: WASF1. Taxonomy: Mus musculus (Mouse). Uniprot ID: Q8R5H6 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ WASF1 |
| Ontology domain: | Cellular Component |
| SynGO term: | postsynapse (GO:0098794) |
| Synapse type(s): | hippocampus |
| Annotated paper: | Pilpel Y, et al. "Rapid WAVE dynamics in dendritic spines of cultured hippocampal neurons is mediated by actin polymerization" J Neurochem. 2005 Dec;95(5):1401-10 PMID:16190876 |
| Figure(s): | fig 4e |
| Annotation description: | Figure 4e shows localisation of WASF1(WAVE1) in puncta, with a preference towards dendritic protrusions and spines, upon over expression of WASF1 through WAVE1-GFP plasmid. |
| Evidence tracking, Biological System: | Cultured neurons |
| Evidence tracking, Protein Targeting: | Over-expression |
| Evidence tracking, Experiment Assay: | Confocal |
| Annotator(s): | Alexandros Kanellopoulos (ORCID:0000-0002-2094-7491) Vittoria Mariano (ORCID:0000-0002-9848-0262) Achsel Tilmann (ORCID:0000-0002-1190-4481) Claudia Bagni (ORCID:0000-0002-4419-210X) |
| Lab: | Department of Fundamental Neurosciences, University of Lausanne, CH-1006 Lausanne, Switzerland; Dept Biomedicine and Prevention, University of Rome Tor Vergata, 00133 Rome, Italy |
| Additional literature: | Table 1S: The protein was detected in MS in mouse (M. musculus; 6-8-week-old 129 Strain) and zebrafish (D. rerio; adult male and females) whole brain synaptosomal preparations. @ PMID:28252024 Detected by Western blot in synaptosome preparations from cortex of 3-week old mice (Fig. 6B, 6D). @ PMID:18805096 WASF1 was detected by Western blot in synaptosome preparations from cortex of 3-week old mice (Fig 1b). @ PMID:24050404 |
| SynGO annotation ID: | 566 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |