| Annotated protein: | Guanine nucleotide-binding protein subunit alpha-13 (G alpha-13) (G-protein subunit alpha-13). Gene symbol: GNA13. Taxonomy: Mus musculus (Mouse). Uniprot ID: P27601 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ GNA13 |
| Ontology domain: | Biological Process |
| SynGO term: | regulation of postsynapse assembly (GO:0150052) |
| Synapse type(s): | cerebellum |
| Annotated paper: | Wang Y, et al. "The GABA(B) receptor mediates neuroprotection by coupling to G(13" Sci Signal. 2021 Oct 19;14(705):eaaz4112 PMID:34665640 |
| Figure(s): | Figures 2, 3, 5, 6 |
| Annotation description: | Fig. 2. Gα13 proteins are required for GABA-B receptor-induced JNK phosphorylation. Fig. 3. Activation of the GABA-B receptor leads to Gα13 protein activation. Fig. 5. GABA-B receptor increases PSD95 phosphorylation and synaptic accumulation. Figure S5: Gα13 but not ERK1/2 is involved in GABA-B receptor-mediated PSD95 phosphorylation and dendrite accumulation in cerebellar granule neurons (CGNs). Fig. 6. Gα13 -JNK is involved in GABA-B receptor-mediated neuronal protection. |
| Evidence tracking, Biological System: | Cultured neurons |
| Evidence tracking, Protein Targeting: | RNAi / shRNA Antagonist / agonist |
| Evidence tracking, Experiment Assay: | Western blot Confocal |
| Annotator(s): | Frank Koopmans (ORCID:0000-0002-4973-5732) Guus Smit (ORCID:0000-0002-2286-1587) Matthijs Verhage (ORCID:0000-0002-2514-0216) |
| Lab: | Department of Functional Genomics, Department of Molecular and Cellular Neurobiology, Center for Neurogenomics and Cognitive Research, Vrije Universiteit Amsterdam, 1081 HV Amsterdam, The Netherlands |
| Additional literature: | "Nogo-A-Δ20 binds S1PR2 on sites distinct from the pocket of the sphingolipid sphingosine 1-phosphate (S1P) and signals via the G protein G13, the Rho GEF LARG, and RhoA." @ PMID:24453941 |
| SynGO annotation ID: | 5587 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |