Annotated protein:Guanine nucleotide-binding protein subunit alpha-13 (G alpha-13) (G-protein subunit alpha-13). Gene symbol: GNA13. Taxonomy: Mus musculus (Mouse). Uniprot ID: P27601
antibody wiki:
SynGO gene info:SynGO data @ GNA13
Ontology domain:Cellular Component
SynGO term:postsynapse (GO:0098794)
Synapse type(s):cerebellum
Annotated paper:Wang Y, et al. "The GABA(B) receptor mediates neuroprotection by coupling to G(13" Sci Signal. 2021 Oct 19;14(705):eaaz4112 PMID:34665640
Figure(s):Figures 2, 3, 5, 6
Annotation description:Fig. 2. Gα13 proteins are required for GABA-B receptor-induced JNK phosphorylation.

Fig. 3. Activation of the GABA-B receptor leads to Gα13 protein activation.

Fig. 5. GABA-B receptor increases PSD95 phosphorylation and synaptic accumulation.

Figure S5: Gα13 but not ERK1/2 is involved in GABA-B receptor-mediated PSD95 phosphorylation and dendrite accumulation in cerebellar granule neurons (CGNs).

Fig. 6. Gα13 -JNK is involved in GABA-B receptor-mediated neuronal protection.
Evidence tracking, Biological System:Cultured neurons
Evidence tracking, Protein Targeting:RNAi / shRNA
Antagonist / agonist
Evidence tracking, Experiment Assay:Western blot
Confocal
Annotator(s):Frank Koopmans (ORCID:0000-0002-4973-5732)
Guus Smit (ORCID:0000-0002-2286-1587)
Matthijs Verhage (ORCID:0000-0002-2514-0216)
Lab:Department of Functional Genomics, Department of Molecular and Cellular Neurobiology, Center for Neurogenomics and Cognitive Research, Vrije Universiteit Amsterdam, 1081 HV Amsterdam, The Netherlands
SynGO annotation ID:5586
Dataset release (version):20231201
View annotation as GO-CAM model:Gene Ontology