| Annotated protein: | 5-hydroxytryptamine receptor 4 (5-HT-4) (5-HT4) (Serotonin receptor 4). Gene symbol: HTR4. Taxonomy: Mus musculus (Mouse). Uniprot ID: P97288 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ HTR4 |
| Ontology domain: | Biological Process |
| SynGO term: | regulation of postsynapse assembly (GO:0150052) |
| Synapse type(s): | hippocampus, glutamatergic |
| Annotated paper: | Schill Y, et al. "Serotonin 5-HT(4) receptor boosts functional maturation of dendritic spines via RhoA-dependent control of F-actin" Commun Biol. 2020 Feb 14;3(1):76 PMID:32060357 |
| Figure(s): | Figures 3-5 |
| Annotation description: | Figure 3: 5-HT4R activation increases cofilin phosphorylation and induces spine maturation in hippocampal neurons. Figure 4: 5-HT4R activation boosts the RhoA activity and accumulation of F-actin within individual spines. Figure 5: 5-HT4R/RhoA signaling mediates dendritic spine maturation in the hippocampal tissue. |
| Evidence tracking, Biological System: | Cultured neurons |
| Evidence tracking, Protein Targeting: | Antagonist / agonist Genetic transformation (eg; knockout, knockin, mutations) |
| Evidence tracking, Experiment Assay: | FRET Confocal |
| Annotator(s): | Frank Koopmans (ORCID:0000-0002-4973-5732) Guus Smit (ORCID:0000-0002-2286-1587) Matthijs Verhage (ORCID:0000-0002-2514-0216) |
| Lab: | Department of Functional Genomics, Department of Molecular and Cellular Neurobiology, Center for Neurogenomics and Cognitive Research, Vrije Universiteit Amsterdam, 1081 HV Amsterdam, The Netherlands |
| Additional literature: | - 5-HT signaling controls t-LTD in striatal projection neurons of the direct pathway - 5-HT signaling shapes dendritic Ca2+ signals - 5-HT-mediated regulation of t-LTD biases thalamostriatal synapses - Gating of t-LTD requires dampened activity of the 5-HT4R subtype, which modulates BK channel function @ PMID:29706583 |
| SynGO annotation ID: | 5585 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |