| Annotated protein: | 5-hydroxytryptamine receptor 4 (5-HT-4) (5-HT4) (Serotonin receptor 4). Gene symbol: HTR4. Taxonomy: Mus musculus (Mouse). Uniprot ID: P97288 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ HTR4 |
| Ontology domain: | Cellular Component |
| SynGO term: | postsynapse (GO:0098794) |
| Synapse type(s): | striatum, glutamatergic |
| Annotated paper: | Cavaccini A, et al. "Serotonergic Signaling Controls Input-Specific Synaptic Plasticity at Striatal Circuits" Neuron. 2018 May 16;98(4):801-816.e7 PMID:29706583 |
| Figure(s): | Figure 6 |
| Annotation description: | Figure 6: immunofluorescence microscopy showed 5-HT4R (gene HTR4, Serotonin receptor 4) localized to postsynapses in the dorsal striatum (that specifically received input from thalamic glutamatergic presynapses). Localization to dendritic spines was approx 30% |
| Evidence tracking, Biological System: | Intact tissue |
| Evidence tracking, Protein Targeting: | Antibody (detection) |
| Evidence tracking, Experiment Assay: | Confocal |
| Annotator(s): | Frank Koopmans (ORCID:0000-0002-4973-5732) Guus Smit (ORCID:0000-0002-2286-1587) Matthijs Verhage (ORCID:0000-0002-2514-0216) |
| Lab: | Department of Functional Genomics, Department of Molecular and Cellular Neurobiology, Center for Neurogenomics and Cognitive Research, Vrije Universiteit Amsterdam, 1081 HV Amsterdam, The Netherlands |
| SynGO annotation ID: | 5584 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |