| Annotated protein: | Neurochondrin (M-Sema F-associating protein of 75 kDa) (Norbin). Gene symbol: NCDN. Taxonomy: Mus musculus (Mouse). Uniprot ID: Q9Z0E0 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ NCDN |
| Ontology domain: | Biological Process |
| SynGO term: | regulation of postsynaptic neurotransmitter receptor endocytosis (GO:0099149) |
| Synapse type(s): | hippocampus, glutamatergic |
| Annotated paper: | Ojha P, et al. "Regulation of Metabotropic Glutamate Receptor Internalization and Synaptic AMPA Receptor Endocytosis by the Postsynaptic Protein Norbin" J Neurosci. 2022 Feb 2;42(5):731-748 PMID:34907024 |
| Figure(s): | 7, 9 |
| Annotation description: | Figure 7: Norbin specifically regulates the mGluR-mediated AMPAR endocytosis. Figure 9: PKA binding to AMPARs through Norbin is critical for the mGluR-mediated AMPAR endocytosis. authors conclude: "Together, these results suggest that activation of Group I mGluRs led to enhanced interaction of PKA with the AMPARs, which is essential for the mGluR-mediated AMPAR endocytosis; and Norbin acts as a scaffolding protein which recruits PKA to the AMPARs subsequent to the activation of Group I mGluRs." |
| Evidence tracking, Biological System: | Cultured neurons |
| Evidence tracking, Protein Targeting: | RNAi / shRNA |
| Evidence tracking, Experiment Assay: | Confocal IP + WB/MSMS |
| Annotator(s): | Frank Koopmans (ORCID:0000-0002-4973-5732) Guus Smit (ORCID:0000-0002-2286-1587) Matthijs Verhage (ORCID:0000-0002-2514-0216) |
| Lab: | Department of Functional Genomics, Department of Molecular and Cellular Neurobiology, Center for Neurogenomics and Cognitive Research, Vrije Universiteit Amsterdam, 1081 HV Amsterdam, The Netherlands |
| Additional literature: | Figure 3: "Effects of Norbin on the abundance of mGluR5 at the cell surface" "Genetic deletion of Norbin attenuates mGluR5-dependent stable changes in synaptic function measured as long-term depression or long-term potentiation of synaptic transmission in the hippocampus." @ PMID:20007903 |
| SynGO annotation ID: | 5581 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |