| Annotated protein: | Transmembrane protein 240. Gene symbol: TMEM240. Taxonomy: Mus musculus (Mouse). Uniprot ID: B2RWJ3 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ TMEM240 |
| Ontology domain: | Cellular Component |
| SynGO term: | integral component of postsynaptic density membrane (GO:0099061) |
| Synapse type(s): | Parallel fibre (cerebellum -> Purkinje-cell) Cerebellar climbing fiber to Purkinje cell synapse |
| Annotated paper: | Homa M, et al. "The TMEM240 Protein, Mutated in SCA21, Is Expressed in Purkinje Cells and Synaptic Terminals" Cerebellum. 2020 Jun;19(3):358-369 PMID:32002801 |
| Figure(s): | Figure 6-8 |
| Annotation description: | Figure 6e: TMEM240 was detected in PSD biochemical fractions prepared from mouse brain. Figure 6, 8: Double immunostaining of TMEM240 and synaptophysin in mouse (Fig.6) and human (Fig.8) brain sections. Figure 7: Transmission electron micrographs of TMEM240 immunogold staining of murine cerebellar sections demonstrated TMEM240 localization on the post-synaptic side of the Purkinje-cell membrane |
| Evidence tracking, Biological System: | Intact tissue |
| Evidence tracking, Protein Targeting: | Antibody (detection) |
| Evidence tracking, Experiment Assay: | Electron Microscopy Confocal |
| Annotator(s): | Frank Koopmans (ORCID:0000-0002-4973-5732) Guus Smit (ORCID:0000-0002-2286-1587) Matthijs Verhage (ORCID:0000-0002-2514-0216) |
| Lab: | Department of Functional Genomics, Department of Molecular and Cellular Neurobiology, Center for Neurogenomics and Cognitive Research, Vrije Universiteit Amsterdam, 1081 HV Amsterdam, The Netherlands |
| SynGO annotation ID: | 5580 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |