| Annotated protein: | Vacuolar protein sorting-associated protein 26B (Vesicle protein sorting 26B). Gene symbol: VPS26B. Taxonomy: Mus musculus (Mouse). Uniprot ID: Q8C0E2 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ VPS26B |
| Ontology domain: | Biological Process |
| SynGO term: | regulation of neurotransmitter receptor localization to postsynaptic specialization membrane (GO:0098696) |
| Synapse type(s): | hippocampus, glutamatergic |
| Annotated paper: | Simoes S, et al. "Alzheimer's vulnerable brain region relies on a distinct retromer core dedicated to endosomal recycling" Cell Rep. 2021 Dec 28;37(13):110182 PMID:34965419 |
| Figure(s): | Fig 3B, 4 5F |
| Annotation description: | Fig 4: VPS26B knockout cultured neurons show a decrease of surface GluA1 by western blot (A) and imaging (C) without affecting total levels of GluA1. In the VPS26B knockout, the GluA1 receptor accumulates in possynaptic early and recycling endosomes (B). The surface levels of GluA1 can be restored by reexpression of VPS26B-GFP. Fig 3B: VPS26B knockout mice show impaired LTP in the trans-entorhinal cortex (TEC). Fig 5F: AAV9-VPS26b-GFP expression in the TEC can restore LTP in VPS26B knockout mice |
| Evidence tracking, Biological System: | Cultured neurons Intact tissue |
| Evidence tracking, Protein Targeting: | Genetic transformation (eg; knockout, knockin, mutations) |
| Evidence tracking, Experiment Assay: | Confocal Electrophysiology (generic) |
| Annotator(s): | Jan van Weering (ORCID:0000-0001-5259-4945) Matthijs Verhage (ORCID:0000-0002-2514-0216) |
| Lab: | Department of Functional Genomics, Center for Neurogenomics and Cognitive Research, Vrije Universiteit Amsterdam, 1081 HV Amsterdam, The Netherlands |
| SynGO annotation ID: | 5553 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |