| Annotated protein: | FERM and PDZ domain-containing protein 4 (PDZ domain-containing protein 10) (PSD-95-interacting regulator of spine morphogenesis) (Preso). Gene symbol: FRMPD4. Taxonomy: Mus musculus (Mouse). Uniprot ID: A2AFR3 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ FRMPD4 |
| Ontology domain: | Cellular Component |
| SynGO term: | postsynaptic density (GO:0014069) |
| Synapse type(s): | hippocampus, glutamatergic |
| Annotated paper: | Hu JH, et al. "Preso1 dynamically regulates group I metabotropic glutamate receptors" Nat Neurosci. 2012 Jun;15(6):836-44 PMID:22561452 |
| Figure(s): | 1 |
| Annotation description: | Figure 1e: Immunogold electron microscopy showed FRMPD4 (also termed PDZD10, PDZK10, Preso, Preso1) gold particles enriched in and adjacent to the PSDs in the hippocampus. Figure 1d: Double immunofluorescent staining with confocal fluorescence microscopy of FRMPD4 and PSD95 (DLG4) showed co-localization at synaptic puncta in cultured hippocampal neurons. No co-localization was observed for GAD65. |
| Evidence tracking, Biological System: | Intact tissue Cultured neurons |
| Evidence tracking, Protein Targeting: | Antibody (detection) |
| Evidence tracking, Experiment Assay: | Confocal Electron Microscopy |
| Annotator(s): | Frank Koopmans (ORCID:0000-0002-4973-5732) Guus Smit (ORCID:0000-0002-2286-1587) Matthijs Verhage (ORCID:0000-0002-2514-0216) |
| Lab: | Department of Functional Genomics, Department of Molecular and Cellular Neurobiology, Center for Neurogenomics and Cognitive Research, Vrije Universiteit Amsterdam, 1081 HV Amsterdam, The Netherlands |
| SynGO annotation ID: | 5546 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |