| Annotated protein: | Seizure 6-like protein (Acupuncture-induced protein 1-L) (Brain-specific receptor-like protein B) (BSRP-B). Gene symbol: SEZ6L. Taxonomy: Mus musculus (Mouse). Uniprot ID: Q6P1D5 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ SEZ6L |
| Ontology domain: | Cellular Component |
| SynGO term: | integral component of postsynaptic membrane (GO:0099055) |
| Synapse type(s): | hippocampus, glutamatergic |
| Annotated paper: | Boudkkazi S, et al. "A Noelin-organized extracellular network of proteins required for constitutive and context-dependent anchoring of AMPA-receptors" Neuron. 2023 Aug 16;111(16):2544-2556.e9 PMID:37591201 |
| Figure(s): | S10 |
| Annotation description: | Figure 4B: OLFM1 pulldowns yield AMPARs and SE6L1 (SEZ6L) as strong interactors. Figure S10: Confocal fluorescence imaging showed SE6L1 localized to postsynaptic membranes in the hippocampal CA1 region by virtue of partial co-localization with the mostly spine-restricted Nrn1 (SE6L1 was homogenously distributed along the dendrite). |
| Evidence tracking, Biological System: | Intact tissue |
| Evidence tracking, Protein Targeting: | Antibody (detection) |
| Evidence tracking, Experiment Assay: | Confocal |
| Annotator(s): | Frank Koopmans (ORCID:0000-0002-4973-5732) Guus Smit (ORCID:0000-0002-2286-1587) Matthijs Verhage (ORCID:0000-0002-2514-0216) |
| Lab: | Department of Functional Genomics, Department of Molecular and Cellular Neurobiology, Center for Neurogenomics and Cognitive Research, Vrije Universiteit Amsterdam, 1081 HV Amsterdam, The Netherlands |
| SynGO annotation ID: | 5529 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |