| Annotated protein: | Large tumor suppressor kinase 1. Gene symbol: LATS1. Taxonomy: Rattus norvegicus (Rat). Uniprot ID: F1M2K4 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ LATS1 |
| Ontology domain: | Cellular Component |
| SynGO term: | postsynapse (GO:0098794) |
| Synapse type(s): | hippocampus, glutamatergic |
| Annotated paper: | Wigerius M, et al. "The polarity protein Angiomotin p130 controls dendritic spine maturation" J Cell Biol. 2018 Feb 5;217(2):715-730 PMID:29317530 |
| Figure(s): | Fig. 7A, F |
| Annotation description: | Lats1 is colocalized with PSD-95 at DIV18 (Fig. 7A) and, upon overexpression, Flag-tagged Lats1 co-localizes with GFP-actin in spines (Fig. 7F). |
| Evidence tracking, Biological System: | Cultured neurons |
| Evidence tracking, Protein Targeting: | Antibody (detection) Over-expression |
| Evidence tracking, Experiment Assay: | Confocal |
| Annotator(s): | Daniela Dieterich (ORCID:0000-0002-9880-1214) Rainer Pielot (ORCID:0000-0002-9681-3318) Karl-Heinz Smalla (ORCID:0000-0002-0269-0311) Eckart Gundelfinger (ORCID:0000-0001-9377-7414) |
| Lab: | Leibniz Institute for Neurobiology (LIN), Institute of Pharmacology and Toxicology, Otto von Guericke University, Center for Behavioral Brain Sciences (CBBS), Magdeburg, Germany |
| SynGO annotation ID: | 5526 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |