| Annotated protein: | Angiomotin. Gene symbol: AMOT. Taxonomy: Rattus norvegicus (Rat). Uniprot ID: A0A0G2JX94 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ AMOT |
| Ontology domain: | Cellular Component |
| SynGO term: | postsynaptic density (GO:0014069) |
| Synapse type(s): | hippocampus, glutamatergic |
| Annotated paper: | Wigerius M, et al. "The polarity protein Angiomotin p130 controls dendritic spine maturation" J Cell Biol. 2018 Feb 5;217(2):715-730 PMID:29317530 |
| Figure(s): | Fig. 1E-H; Fig. 2 |
| Annotation description: | Angiomotin colocalizes with PSD-95 (Fig. 1F); it is present in the highly enriched PSD fraction (Fig. 1E) and coIPs with PSD-95 and MUPP1/MPDZ (Fig 1G-I); Fig. 2 provides evidence that over-expressed YFP-tagged AMOT co-distributes with the presynaptic marker Bassoon and the excitatory postsynaptic markers PSD-95 and Mupp1, but not with the inhibitory postsynaptic marker Gephyrin. |
| Evidence tracking, Biological System: | Cultured neurons Intact tissue |
| Evidence tracking, Protein Targeting: | Antibody (detection) Over-expression |
| Evidence tracking, Experiment Assay: | Confocal Western blot Biochemical fractionation (generic) IP + WB/MSMS |
| Annotator(s): | Daniela Dieterich (ORCID:0000-0002-9880-1214) Rainer Pielot (ORCID:0000-0002-9681-3318) Karl-Heinz Smalla (ORCID:0000-0002-0269-0311) Eckart Gundelfinger (ORCID:0000-0001-9377-7414) |
| Lab: | Leibniz Institute for Neurobiology (LIN), Institute of Pharmacology and Toxicology, Otto von Guericke University, Center for Behavioral Brain Sciences (CBBS), Magdeburg, Germany |
| SynGO annotation ID: | 5525 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |