| Annotated protein: | Testican-1 (Protein SPOCK). Gene symbol: SPOCK1. Taxonomy: Mus musculus (Mouse). Uniprot ID: Q62288 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ SPOCK1 |
| Ontology domain: | Cellular Component |
| SynGO term: | postsynaptic density (GO:0014069) |
| Synapse type(s): | hippocampus cerebellum cerebral cortex |
| Annotated paper: | Bonnet F, et al. "Structure and cellular distribution of mouse brain testican. Association with the postsynaptic area of hippocampus pyramidal cells" J Biol Chem. 1996 Feb 23;271(8):4373-80 PMID:8626787 |
| Figure(s): | Figure 6 |
| Annotation description: | Figure 6: "Immunoelectron microscopic localization of testican. Testican localization in the postsynaptic portion of synapses present in the stratum lucidum of the hippocampus (a, b), cortex (c, d), and molecular layer of the cerebellum (e) of a 21-day-old mouse brain after incubation with PTC9 antiserum (1:500). The labeling (open arrows) is strong on the postsynaptic (Po) density and faint in the immediate cytoplasmic fluid. No labeling is present in the synaptic cleft. The corresponding presynaptic areas (Pr), clearly identified by the presence of synaptic vesicles, are also negative; not all the postsynaptic densities are immunostained." |
| Evidence tracking, Biological System: | Intact tissue |
| Evidence tracking, Protein Targeting: | Antibody (detection) |
| Evidence tracking, Experiment Assay: | Electron Microscopy |
| Annotator(s): | Frank Koopmans (ORCID:0000-0002-4973-5732) Guus Smit (ORCID:0000-0002-2286-1587) Matthijs Verhage (ORCID:0000-0002-2514-0216) |
| Lab: | Department of Functional Genomics, Department of Molecular and Cellular Neurobiology, Center for Neurogenomics and Cognitive Research, Vrije Universiteit Amsterdam, 1081 HV Amsterdam, The Netherlands |
| SynGO annotation ID: | 5516 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |