| Annotated protein: | Brain-specific angiogenesis inhibitor 1-associated protein 2 (BAI-associated protein 2) (BAI1-associated protein 2) (Insulin receptor substrate protein of 53 kDa) (IRSp53) (Insulin receptor substrate p53) (Insulin receptor tyrosine kinase 53 kDa substrate). Gene symbol: BAIAP2. Taxonomy: Mus musculus (Mouse). Uniprot ID: Q8BKX1 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ BAIAP2 |
| Ontology domain: | Biological Process |
| SynGO term: | modulation of chemical synaptic transmission (GO:0050804) |
| Synapse type(s): | Schaffer collateral synapse (CA3->CA1) |
| Annotated paper: | Kim MH, et al. "Enhanced NMDA receptor-mediated synaptic transmission, enhanced long-term potentiation, and impaired learning and memory in mice lacking IRSp53" J Neurosci. 2009 Feb 4;29(5):1586-95 PMID:19193906 |
| Figure(s): | fig 5; 6; 7 |
| Annotation description: | Electrophysiological evidences show decreased AMPA/NMDA ratio of eEPSCs and enhanced LTP at IRSp53-/- SC-CA1 synapses, compared with WT mice. Furthermore amplitude but not frequency, of NMDA receptor-mediated mEPSCs is enhanced at IRSp53-/- SC-CA1 synapses and enhanced NMDA receptor-mediated synaptic transmission during the delivery of TBS. |
| Evidence tracking, Biological System: | Intact tissue |
| Evidence tracking, Protein Targeting: | Genetic transformation (eg; knockout, knockin, mutations) |
| Evidence tracking, Experiment Assay: | Whole-cell patch clamp Field recordings |
| Annotator(s): | Alexandros Kanellopoulos (ORCID:0000-0002-2094-7491) Vittoria Mariano (ORCID:0000-0002-9848-0262) Achsel Tilmann (ORCID:0000-0002-1190-4481) Claudia Bagni (ORCID:0000-0002-4419-210X) |
| Lab: | Department of Fundamental Neurosciences, University of Lausanne, CH-1006 Lausanne, Switzerland; Dept Biomedicine and Prevention, University of Rome Tor Vergata, 00133 Rome, Italy |
| Additional literature: | [human] --> " Human IRSp53 cDNA...." Overexpression of IRSp53 in rat cultured neurons selectively increases the density of dendritic spines, while siRNA downregulation of IRSp53 decreases the density and size of spines (Fig. 6 and 7) @ PMID:15673667 |
| SynGO annotation ID: | 550 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |