| Annotated protein: | WW and C2 domain containing 1. Gene symbol: WWC1. Taxonomy: Rattus norvegicus (Rat). Uniprot ID: F1M6U0 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ WWC1 |
| Ontology domain: | Cellular Component |
| SynGO term: | postsynaptic density, intracellular component (GO:0099092) |
| Synapse type(s): | hippocampus |
| Annotated paper: | Johannsen S, et al. "Temporal-spatial expression and novel biochemical properties of the memory-related protein KIBRA" Neuroscience. 2008 Sep 9;155(4):1165-73 PMID:18672031 |
| Figure(s): | Fig. 4 |
| Annotation description: | "The KIBRA/WWC1 signal in dendrites was in close apposition with the presynaptic marker Bassoon and co-localized partially with the postsynaptic protein ProSAP2/Shank3, suggesting a postsynaptic localization of KIBRA" in primary cultures of rat hippocampal neurons at 17DIV (legend to Fig. 4). Moreover Fig. 4B documents the enrichment of Kibra immunoreactivity in postsynaptic density biochemical fractions prepared from adult rat brain. |
| Evidence tracking, Biological System: | Cultured neurons Intact tissue |
| Evidence tracking, Protein Targeting: | Antibody (detection) |
| Evidence tracking, Experiment Assay: | Microscopy (generic) Western blot Biochemical fractionation (generic) |
| Annotator(s): | Daniela Dieterich (ORCID:0000-0002-9880-1214) Rainer Pielot (ORCID:0000-0002-9681-3318) Karl-Heinz Smalla (ORCID:0000-0002-0269-0311) Eckart Gundelfinger (ORCID:0000-0001-9377-7414) |
| Lab: | Leibniz Institute for Neurobiology (LIN), Institute of Pharmacology and Toxicology, Otto von Guericke University, Center for Behavioral Brain Sciences (CBBS), Magdeburg, Germany |
| SynGO annotation ID: | 5499 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |