Annotated protein:Acid-sensing ion channel 1 (ASIC1) (Acid-sensing ion channel) (Amiloride-sensitive cation channel 2, neuronal) (Brain sodium channel 2) (BNaC2). Gene symbol: ASIC1. Taxonomy: Mus musculus (Mouse). Uniprot ID: Q6NXK8
antibody wiki:
SynGO gene info:SynGO data @ ASIC1
Ontology domain:Biological Process
SynGO term:regulation of postsynapse assembly (GO:0150052)
Synapse type(s):hippocampus, glutamatergic
Annotated paper:Zha XM, et al. "Acid-sensing ion channel 1a is a postsynaptic proton receptor that affects the density of dendritic spines" Proc Natl Acad Sci U S A. 2006 Oct 31;103(44):16556-61 PMID:17060608
Figure(s):Figure 2, 3, 7
Annotation description:"ASIC1a Increased the Density of Dendritic Spines.
While examining ASIC1a localization, we were surprised to find that transfecting hippocampal slice neurons with ASIC1a increased spine density >20% (Fig. 2). As an additional test, we studied hippocampal slices from ASIC1a transgenic mice and observed a similar increased spine density (Fig. 2). In contrast to the effects of ASIC1a, expressing ASIC2a, which is highly homologous to ASIC1a but much less pH-sensitive, failed to alter spine density (Fig. 2B)."

Figure 3: Reducing ASIC1a decreased spine density.

Figure 7: The CaMKII inhibitory peptide AIP inhibited the ASIC1a-induced increase in spine density.
Evidence tracking, Biological System:Intact tissue
Cultured neurons
Evidence tracking, Protein Targeting:Over-expression
Genetic transformation (eg; knockout, knockin, mutations)
Evidence tracking, Experiment Assay:Confocal
Annotator(s):Frank Koopmans (ORCID:0000-0002-4973-5732)
Guus Smit (ORCID:0000-0002-2286-1587)
Matthijs Verhage (ORCID:0000-0002-2514-0216)
Lab:Department of Functional Genomics, Department of Molecular and Cellular Neurobiology, Center for Neurogenomics and Cognitive Research, Vrije Universiteit Amsterdam, 1081 HV Amsterdam, The Netherlands
SynGO annotation ID:5478
Dataset release (version):20231201
View annotation as GO-CAM model:Gene Ontology