| Annotated protein: | Acid-sensing ion channel 2 (ASIC2) (Amiloride-sensitive brain sodium channel) (Amiloride-sensitive cation channel 1, neuronal) (Brain sodium channel 1) (BNC1) (BNaC1). Gene symbol: ASIC2. Taxonomy: Mus musculus (Mouse). Uniprot ID: Q925H0 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ ASIC2 |
| Ontology domain: | Biological Process |
| SynGO term: | regulation of postsynapse assembly (GO:0150052) |
| Annotated paper: | Zha XM, et al. "ASIC2 subunits target acid-sensing ion channels to the synapse via an association with PSD-95" J Neurosci. 2009 Jul 1;29(26):8438-46 PMID:19571134 |
| Figure(s): | Figure 8 |
| Annotation description: | Figure 2: ASIC2a associates with PSD-95 through its PDZ-binding domain. Figure 3: PSD-95 increases ASIC2a in spines. Figure 5: Endogenous ASIC2 enriches in synaptosomes and coimmunoprecipitates with ASIC1. Figure 8: Eliminating ASIC2 decreases the density of dendritic spines. "We found that disrupting the ASIC2 gene reduced the density of synapses (Fig. 8A,B). The reduction was primarily due to a decrease in spine synapses, with no effect on the density of shaft synapses." |
| Evidence tracking, Biological System: | Cultured neurons Intact tissue |
| Evidence tracking, Protein Targeting: | Genetic transformation (eg; knockout, knockin, mutations) |
| Evidence tracking, Experiment Assay: | Western blot Biochemical fractionation (generic) Confocal |
| Annotator(s): | Frank Koopmans (ORCID:0000-0002-4973-5732) Guus Smit (ORCID:0000-0002-2286-1587) Matthijs Verhage (ORCID:0000-0002-2514-0216) |
| Lab: | Department of Functional Genomics, Department of Molecular and Cellular Neurobiology, Center for Neurogenomics and Cognitive Research, Vrije Universiteit Amsterdam, 1081 HV Amsterdam, The Netherlands |
| SynGO annotation ID: | 5477 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |