| Annotated protein: | Ras-specific guanine nucleotide-releasing factor 2 (Ras-GRF2) (Ras guanine nucleotide exchange factor 2). Gene symbol: RASGRF2. Taxonomy: Mus musculus (Mouse). Uniprot ID: P70392 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ RASGRF2 |
| Ontology domain: | Biological Process |
| SynGO term: | postsynaptic modulation of chemical synaptic transmission (GO:0099170) |
| Synapse type(s): | hippocampus, glutamatergic |
| Annotated paper: | Schwechter B, et al. "RasGRF2 Rac-GEF activity couples NMDA receptor calcium flux to enhanced synaptic transmission" Proc Natl Acad Sci U S A. 2013 Aug 27;110(35):14462-7 PMID:23940355 |
| Figure(s): | Figure 3 |
| Annotation description: | Figure 1: NMDAR-dependent LTP is reduced in mature, but not immature, Ras-GRF double knock-out mice. Figure 2: NMDAR-dependent LTD generation is also defective in postpubescent, but not prepubescent, Ras-GRF double knock-out mice. Figure 3: Ras-GRF1 contributes predominantly to LTD, whereas Ras-GRF2 contributes predominantly to LTP in mature mice. Figure 4: Ras-GRF2 is a major regulator of Erk activation via NR2A subunit-containing NMDARs, whereas Ras-GRF1 is a minor regulator of Erk activation via NR2B-containing NMDARs in mature mice. Figure 6: Ras-GRF2, but not Ras-GRF1, contributes to a form of short-term plasticity. |
| Evidence tracking, Biological System: | Intact tissue |
| Evidence tracking, Protein Targeting: | Genetic transformation (eg; knockout, knockin, mutations) |
| Evidence tracking, Experiment Assay: | Whole-cell patch clamp Western blot |
| Annotator(s): | Frank Koopmans (ORCID:0000-0002-4973-5732) Guus Smit (ORCID:0000-0002-2286-1587) Matthijs Verhage (ORCID:0000-0002-2514-0216) |
| Lab: | Department of Functional Genomics, Department of Molecular and Cellular Neurobiology, Center for Neurogenomics and Cognitive Research, Vrije Universiteit Amsterdam, 1081 HV Amsterdam, The Netherlands |
| Additional literature: | "Here, we demonstrate that Ras-GRF2 is a bifunctional signaling protein that is able to bind and activate Ras and Rac, and thereby coordinate the activation of the extracellular-signal-regulated kinase (ERK) and stress-activated protein kinase (SAPK) pathways." @ PMID:9707409 |
| SynGO annotation ID: | 5463 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |