| Annotated protein: | Kinesin-like protein KIF2C (Mitotic centromere-associated kinesin) (MCAK). Gene symbol: KIF2C. Taxonomy: Mus musculus (Mouse). Uniprot ID: Q922S8 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ KIF2C |
| Ontology domain: | Cellular Component |
| SynGO term: | presynapse (GO:0098793) |
| Synapse type(s): | hippocampus, glutamatergic |
| Annotated paper: | Zheng R, et al. "KIF2C regulates synaptic plasticity and cognition in mice through dynamic microtubule depolymerization" Elife. 2022 Feb 9;11:e72483 PMID:35138249 |
| Figure(s): | Figure 1 |
| Annotation description: | Figure 1d: KIF2C was expressed in all synaptic biochemical fractions prepared from mouse hippocampus, including synaptosomes, presynaptic fractions and PSD. Strongest enrichment was observed in the latter. Figure 1e: confocal immunofluorescence imaging of hippocampal neurons double-labeled for KIF2C and either PSD95 (DLG4) or Bassoon (BSN) showed partial co-localization with both marker proteins, suggesting KIF2C is localized to both pre- and post-synapse. |
| Evidence tracking, Biological System: | Intact tissue Cultured neurons |
| Evidence tracking, Protein Targeting: | Antibody (detection) |
| Evidence tracking, Experiment Assay: | Western blot Biochemical fractionation (generic) Confocal |
| Annotator(s): | Frank Koopmans (ORCID:0000-0002-4973-5732) Guus Smit (ORCID:0000-0002-2286-1587) Matthijs Verhage (ORCID:0000-0002-2514-0216) |
| Lab: | Department of Functional Genomics, Department of Molecular and Cellular Neurobiology, Center for Neurogenomics and Cognitive Research, Vrije Universiteit Amsterdam, 1081 HV Amsterdam, The Netherlands |
| SynGO annotation ID: | 5441 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |