Annotated protein:Kinesin-like protein KIF2C (Mitotic centromere-associated kinesin) (MCAK). Gene symbol: KIF2C. Taxonomy: Mus musculus (Mouse). Uniprot ID: Q922S8
antibody wiki:
SynGO gene info:SynGO data @ KIF2C
Ontology domain:Cellular Component
SynGO term:presynapse (GO:0098793)
Synapse type(s):hippocampus, glutamatergic
Annotated paper:Zheng R, et al. "KIF2C regulates synaptic plasticity and cognition in mice through dynamic microtubule depolymerization" Elife. 2022 Feb 9;11:e72483 PMID:35138249
Figure(s):Figure 1
Annotation description:Figure 1d: KIF2C was expressed in all synaptic biochemical fractions prepared from mouse hippocampus, including synaptosomes, presynaptic fractions and PSD. Strongest enrichment was observed in the latter.

Figure 1e: confocal immunofluorescence imaging of hippocampal neurons double-labeled for KIF2C and either PSD95 (DLG4) or Bassoon (BSN) showed partial co-localization with both marker proteins, suggesting KIF2C is localized to both pre- and post-synapse.
Evidence tracking, Biological System:Intact tissue
Cultured neurons
Evidence tracking, Protein Targeting:Antibody (detection)
Evidence tracking, Experiment Assay:Western blot
Biochemical fractionation (generic)
Confocal
Annotator(s):Frank Koopmans (ORCID:0000-0002-4973-5732)
Guus Smit (ORCID:0000-0002-2286-1587)
Matthijs Verhage (ORCID:0000-0002-2514-0216)
Lab:Department of Functional Genomics, Department of Molecular and Cellular Neurobiology, Center for Neurogenomics and Cognitive Research, Vrije Universiteit Amsterdam, 1081 HV Amsterdam, The Netherlands
SynGO annotation ID:5441
Dataset release (version):20231201
View annotation as GO-CAM model:Gene Ontology