Annotated protein: | Leucine-rich repeat transmembrane neuronal protein 4. Gene symbol: LRRTM4. Taxonomy: Rattus norvegicus (Rat). Uniprot ID: B4F7C5 |
antibody wiki: | |
SynGO gene info: | SynGO data @ LRRTM4 |
Ontology domain: | Cellular Component |
SynGO term: | integral component of postsynaptic density membrane (GO:0099061) |
Synapse type(s): | hippocampus, glutamatergic |
Annotated paper: | de Wit J, et al. "Unbiased discovery of glypican as a receptor for LRRTM4 in regulating excitatory synapse development" Neuron. 2013 Aug 21;79(4):696-711 PMID:23911103 |
Figure(s): | Fig. 3c,d |
Annotation description: | Fig. 3c,d LRRTM4 localizes to the postsynaptic density of glutamatergic synapses Literal "LRRTM4 puncta partially overlapped with the presynaptic excitatory marker VGlut1 (Figure 3C) and colocalized with the postsynaptic glutamate receptor subunit GluR1 (Figure 3D)." 15/5/2017 Pim - There is reason to interpret the low-resolution data to support post-synaptic localization of LRRTM4. 1. Literal: "The LRRTM4 transcript is only expressed in DG granule cells in this region (Figure 3A), suggesting that LRRTM4 localizes to granule cell dendrites" --> in the postsynaptic neuron 2. Literal: " LRRTM4 puncta partially overlapped with the presynaptic excitatory marker VGlut1 (Figure 3C) and colocalized with the postsynaptic glutamate receptor subunit GluR1 (Figure 3D)." -> sign of localization in synaptic cleft. Authors conclude: "These data suggest that endogenous LRRTM4 localizes to the postsynaptic density of glutamatergic synapses" |
Evidence tracking, Biological System: | Cultured neurons |
Evidence tracking, Protein Targeting: | Antibody (detection) |
Evidence tracking, Experiment Assay: | Confocal |
Annotator(s): | Chiara Verpelli (ORCID:0000-0003-2949-9725) Carlo Sala (ORCID:0000-0003-0662-9523) |
Lab: | CNR Neuroscience Institute Milan and Dept. of Biotechnology and Translational Medicine, University of Milan, 20129 Milan, Italy |
SynGO annotation ID: | 544 |
Dataset release (version): | 20231201 |
View annotation as GO-CAM model: |