| Annotated protein: | Protein TANC2. Gene symbol: TANC2. Taxonomy: Rattus norvegicus (Rat). Uniprot ID: F1LTE0 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ TANC2 |
| Ontology domain: | Cellular Component |
| SynGO term: | postsynaptic density (GO:0014069) |
| Synapse type(s): | hippocampus, glutamatergic |
| Annotated paper: | Stucchi R, et al. "Regulation of KIF1A-Driven Dense Core Vesicle Transport: Ca(2+)/CaM Controls DCV Binding and Liprin-alpha/TANC2 Recruits DCVs to Postsynaptic Sites" Cell Rep. 2018 Jul 17;24(3):685-700 PMID:30021165 |
| Figure(s): | Figure 6, S4 |
| Annotation description: | Figure 6, S4: immunofluorescence imaging of overexpressed TANC2 in hippocampal neurons showed enrichment in dendritic spines and strong co-localization with PSD marker proteins PSD95 (DLG4) and Homer. Analysis of the truncated isoforms revealed that the C-terminal part of TANC2 (1501-1900), which includes the PDZ binding domain, is responsible for the synaptic localization (Figure S4A). Further, TANC2 pulldowns suggested interaction with various PSD proteins. |
| Evidence tracking, Biological System: | Cultured neurons |
| Evidence tracking, Protein Targeting: | Over-expression |
| Evidence tracking, Experiment Assay: | Confocal IP + WB/MSMS |
| Annotator(s): | Frank Koopmans (ORCID:0000-0002-4973-5732) Guus Smit (ORCID:0000-0002-2286-1587) Matthijs Verhage (ORCID:0000-0002-2514-0216) |
| Lab: | Department of Functional Genomics, Department of Molecular and Cellular Neurobiology, Center for Neurogenomics and Cognitive Research, Vrije Universiteit Amsterdam, 1081 HV Amsterdam, The Netherlands |
| Additional literature: | TANC2 is a synaptic scaffold, interacting and co-localizing with the synaptic anchoring proteins PSD-95 and Homer @ PMID:21068316 |
| SynGO annotation ID: | 5433 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |