| Annotated protein: | Appetite-regulating hormone (Growth hormone secretagogue) (Growth hormone-releasing peptide) (Motilin-related peptide) (Protein M46) [Cleaved into: Ghrelin; Obestatin]. Gene symbol: GHRL. Taxonomy: Mus musculus (Mouse). Uniprot ID: Q9EQX0 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ GHRL |
| Ontology domain: | Cellular Component |
| SynGO term: | neuronal dense core vesicle lumen (GO:0099013) |
| Synapse type(s): | hypothalamus |
| Annotated paper: | Cowley MA, et al. "The distribution and mechanism of action of ghrelin in the CNS demonstrates a novel hypothalamic circuit regulating energy homeostasis" Neuron. 2003 Feb 20;37(4):649-61 PMID:12597862 |
| Figure(s): | Figure 2 |
| Annotation description: | Figure 2i: "Electron micrograph showing ghrelin immunoreactivity in dense-cored vesicles of an axon terminal." Figure 2j: "Electron micrograph showing a symmetrical synaptic membrane specialization (black arrows) between a ghrelin-immunolabeled axon terminal (25 nm immunogold in dense-cored vesicles) and an unlabeled dendrite." Figure 2k: "Electron microscopy revealed direct appositions between ghrelin (immuno peroxidase in dense-cored vesicles) and NPY-producing presynaptic terminals (25 nm immunogold in dense-cored vesicles)." |
| Evidence tracking, Biological System: | Intact tissue |
| Evidence tracking, Protein Targeting: | Antibody (detection) |
| Evidence tracking, Experiment Assay: | Electron Microscopy |
| Annotator(s): | Frank Koopmans (ORCID:0000-0002-4973-5732) Guus Smit (ORCID:0000-0002-2286-1587) Matthijs Verhage (ORCID:0000-0002-2514-0216) |
| Lab: | Department of Functional Genomics, Department of Molecular and Cellular Neurobiology, Center for Neurogenomics and Cognitive Research, Vrije Universiteit Amsterdam, 1081 HV Amsterdam, The Netherlands |
| SynGO annotation ID: | 5430 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |