| Annotated protein: | Microtubule-associated protein 1B (MAP-1B) (MAP1(X)) (MAP1.2) [Cleaved into: MAP1B heavy chain; MAP1 light chain LC1]. Gene symbol: MAP1B. Taxonomy: Mus musculus (Mouse). Uniprot ID: P14873 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ MAP1B |
| Ontology domain: | Biological Process |
| SynGO term: | regulation of postsynapse assembly (GO:0150052) |
| Synapse type(s): | hippocampus, glutamatergic |
| Annotated paper: | Tortosa E, et al. "Microtubule-associated protein 1B (MAP1B) is required for dendritic spine development and synaptic maturation" J Biol Chem. 2011 Nov 25;286(47):40638-48 PMID:21984824 |
| Figure(s): | Figure 3, 4 |
| Annotation description: | Figure 3, 4: confocal imaging of 21DIV hippocampal MAP1B+/+ and MAP1B-/- neurons showed the knockout abolished the maturation of dendritic spines (lower density, longer filepodia, reduced mushroom spines). authors conclude: "Taken together, these results indicate a new and important role for MAP1B in the formation and maturation of dendritic spines, possibly through the regulation of the actin cytoskeleton." |
| Evidence tracking, Biological System: | Cultured neurons |
| Evidence tracking, Protein Targeting: | Genetic transformation (eg; knockout, knockin, mutations) |
| Evidence tracking, Experiment Assay: | Confocal |
| Annotator(s): | Frank Koopmans (ORCID:0000-0002-4973-5732) Guus Smit (ORCID:0000-0002-2286-1587) Matthijs Verhage (ORCID:0000-0002-2514-0216) |
| Lab: | Department of Functional Genomics, Department of Molecular and Cellular Neurobiology, Center for Neurogenomics and Cognitive Research, Vrije Universiteit Amsterdam, 1081 HV Amsterdam, The Netherlands |
| SynGO annotation ID: | 5417 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |