Annotated protein:Cytoplasmic FMR1-interacting protein 2 (p53-inducible protein 121). Gene symbol: CYFIP2. Taxonomy: Mus musculus (Mouse). Uniprot ID: Q5SQX6
antibody wiki:
SynGO gene info:SynGO data @ CYFIP2
Ontology domain:Cellular Component
SynGO term:synapse (GO:0045202)
Synapse type(s):hippocampus
Annotated paper:O'Neil SD, et al. "Action potential-coupled Rho GTPase signaling drives presynaptic plasticity" Elife. 2021 Jul 16;10:e63756 PMID:34269176
Figure(s):Figure 2
Annotation description:Figure 1: Cyfip2 was detected in proximity labeling of synapsin using BioID.

Figure 2: Cultured hippocampal neurons were infected on DIV0 with AAVs containing the candidate sgRNA and a 2x-HA-V5-Myc HiUGE donor in the corresponding open reading frame. Confocal imaging showed Cyfip2 co-localized with synapsin 1, but the resolution is too low to discern localization to the pre/post-synapse.
Evidence tracking, Biological System:Cultured neurons
Evidence tracking, Protein Targeting:Genetic transformation (eg; knockout, knockin, mutations)
Evidence tracking, Experiment Assay:Confocal
Mass-spectrometry
Annotator(s):Frank Koopmans (ORCID:0000-0002-4973-5732)
Guus Smit (ORCID:0000-0002-2286-1587)
Matthijs Verhage (ORCID:0000-0002-2514-0216)
Lab:Department of Functional Genomics, Department of Molecular and Cellular Neurobiology, Center for Neurogenomics and Cognitive Research, Vrije Universiteit Amsterdam, 1081 HV Amsterdam, The Netherlands
SynGO annotation ID:5402
Dataset release (version):20231201
View annotation as GO-CAM model:Gene Ontology