| Annotated protein: | Reticulon-4 receptor (Nogo receptor) (NgR) (Nogo-66 receptor) (Nogo66 receptor-1) (NgR1). Gene symbol: RTN4R. Taxonomy: Mus musculus (Mouse). Uniprot ID: Q99PI8-2 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ RTN4R |
| Ontology domain: | Biological Process |
| SynGO term: | regulation of postsynapse assembly (GO:0150052) |
| Synapse type(s): | hippocampus, glutamatergic |
| Annotated paper: | Kellner Y, et al. "Nogo-A controls structural plasticity at dendritic spines by rapidly modulating actin dynamics" Hippocampus. 2016 Jun;26(6):816-31 PMID:26748478 |
| Figure(s): | Figure 1, 2, 3 |
| Annotation description: | Figure 1-3: Nogo receptor NgR (aka. NgR1, gene RTN4R) inhibition through a specific antibody, as well as inhibition of Nogo, affects dendritic spine development in CA3 pyramidal neurons. Confocal imaging after application showed spine density and morphology was significantly affected. This was confirmed by FRAP of eGFP-actin in spines. |
| Evidence tracking, Biological System: | Intact tissue |
| Evidence tracking, Protein Targeting: | Antagonist / agonist |
| Evidence tracking, Experiment Assay: | Fluorescence recovery after photobleaching (FRAP) Confocal |
| Annotator(s): | Frank Koopmans (ORCID:0000-0002-4973-5732) Guus Smit (ORCID:0000-0002-2286-1587) Matthijs Verhage (ORCID:0000-0002-2514-0216) |
| Lab: | Department of Functional Genomics, Department of Molecular and Cellular Neurobiology, Center for Neurogenomics and Cognitive Research, Vrije Universiteit Amsterdam, 1081 HV Amsterdam, The Netherlands |
| SynGO annotation ID: | 5392 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |