| Annotated protein: | E3 ubiquitin-protein ligase NEDD4 (EC 2.3.2.26) (HECT-type E3 ubiquitin transferase NEDD4) (Neural precursor cell expressed developmentally down-regulated protein 4) (NEDD-4). Gene symbol: NEDD4. Taxonomy: Mus musculus (Mouse). Uniprot ID: P46935 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ NEDD4 |
| Ontology domain: | Cellular Component |
| SynGO term: | postsynaptic cytosol (GO:0099524) |
| Synapse type(s): | hippocampus, glutamatergic |
| Annotated paper: | Scudder SL, et al. "Synaptic strength is bidirectionally controlled by opposing activity-dependent regulation of Nedd4-1 and USP8" J Neurosci. 2014 Dec 10;34(50):16637-49 PMID:25505317 |
| Figure(s): | Fig. 1b,h,i |
| Annotation description: | Fig. 1b,h,i NEDD4 is synaptically localized. Literal "Specifically, the distribution of HA-Nedd4-1 changed from a diffuse pattern throughout dendrites and soma into a punctate pattern with tightly accumulated signal in dendritic spines (p < 0.001; Fig. 1A,C). Moreover, we found extensive colocalization of HA-Nedd4-1 with the postsynaptic density protein PSD-95 and juxtaposition to the presynaptic protein synapsin I (Fig. 1H,I), indicating a recruitment to synapses." |
| Evidence tracking, Biological System: | Cultured neurons |
| Evidence tracking, Protein Targeting: | Over-expression |
| Evidence tracking, Experiment Assay: | Confocal |
| Annotator(s): | Chiara Verpelli (ORCID:0000-0003-2949-9725) Carlo Sala (ORCID:0000-0003-0662-9523) |
| Lab: | CNR Neuroscience Institute Milan and Dept. of Biotechnology and Translational Medicine, University of Milan, 20129 Milan, Italy |
| SynGO annotation ID: | 538 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |