Annotated protein:Adenylyl cyclase-associated protein 1 (CAP 1). Gene symbol: CAP1. Taxonomy: Mus musculus (Mouse). Uniprot ID: P40124
antibody wiki:
SynGO gene info:SynGO data @ CAP1
Ontology domain:Cellular Component
SynGO term:presynapse (GO:0098793)
Synapse type(s):hippocampus, glutamatergic
Annotated paper:Heinze A, et al. "Functional interdependence of the actin regulators CAP1 and cofilin1 in control of dendritic spine morphology" Cell Mol Life Sci. 2022 Oct 20;79(11):558 PMID:36264429
Figure(s):Figure 1
Annotation description:Figure 1D: immunofluorescence imaging of overexpressed CAP1-GFP in cultured hippocampal neurons showed localization to dendritic spines.

Figure 1H-L: STED super-resolution imaging showed endogenous CAP1 was localized througout both pre- and post-synapse.

"Hippocampal neurons from brain-specific CAP1-KO mice were exploited for control experiments [61], which proved specificity of the antibody (Fig. S1E)."
Evidence tracking, Biological System:Cultured neurons
Evidence tracking, Protein Targeting:Antibody (detection)
Over-expression
Evidence tracking, Experiment Assay:Confocal
Super resolution
Annotator(s):Frank Koopmans (ORCID:0000-0002-4973-5732)
Guus Smit (ORCID:0000-0002-2286-1587)
Matthijs Verhage (ORCID:0000-0002-2514-0216)
Lab:Department of Functional Genomics, Department of Molecular and Cellular Neurobiology, Center for Neurogenomics and Cognitive Research, Vrije Universiteit Amsterdam, 1081 HV Amsterdam, The Netherlands
SynGO annotation ID:5378
Dataset release (version):20231201
View annotation as GO-CAM model:Gene Ontology