| Annotated protein: | Adenylyl cyclase-associated protein 1 (CAP 1). Gene symbol: CAP1. Taxonomy: Mus musculus (Mouse). Uniprot ID: P40124 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ CAP1 |
| Ontology domain: | Cellular Component |
| SynGO term: | presynapse (GO:0098793) |
| Synapse type(s): | hippocampus, glutamatergic |
| Annotated paper: | Heinze A, et al. "Functional interdependence of the actin regulators CAP1 and cofilin1 in control of dendritic spine morphology" Cell Mol Life Sci. 2022 Oct 20;79(11):558 PMID:36264429 |
| Figure(s): | Figure 1 |
| Annotation description: | Figure 1D: immunofluorescence imaging of overexpressed CAP1-GFP in cultured hippocampal neurons showed localization to dendritic spines. Figure 1H-L: STED super-resolution imaging showed endogenous CAP1 was localized througout both pre- and post-synapse. "Hippocampal neurons from brain-specific CAP1-KO mice were exploited for control experiments [61], which proved specificity of the antibody (Fig. S1E)." |
| Evidence tracking, Biological System: | Cultured neurons |
| Evidence tracking, Protein Targeting: | Antibody (detection) Over-expression |
| Evidence tracking, Experiment Assay: | Confocal Super resolution |
| Annotator(s): | Frank Koopmans (ORCID:0000-0002-4973-5732) Guus Smit (ORCID:0000-0002-2286-1587) Matthijs Verhage (ORCID:0000-0002-2514-0216) |
| Lab: | Department of Functional Genomics, Department of Molecular and Cellular Neurobiology, Center for Neurogenomics and Cognitive Research, Vrije Universiteit Amsterdam, 1081 HV Amsterdam, The Netherlands |
| SynGO annotation ID: | 5378 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |