| Annotated protein: | Ras-related C3 botulinum toxin substrate 1 (EC 3.6.5.2) (p21-Rac1). Gene symbol: RAC1. Taxonomy: Mus musculus (Mouse). Uniprot ID: P63001 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ RAC1 |
| Ontology domain: | Cellular Component |
| SynGO term: | anchored component of presynaptic membrane (GO:0099026) |
| Synapse type(s): | hippocampus |
| Annotated paper: | O'Neil SD, et al. "Action potential-coupled Rho GTPase signaling drives presynaptic plasticity" Elife. 2021 Jul 16;10:e63756 PMID:34269176 |
| Figure(s): | Figure 3 |
| Annotation description: | Figure 3: immunogold EM imaging of Rac1 in mouse CA1 hippocampus showed localization to synaptic vesicle membranes and pre-/post-synaptic plasma membranes. |
| Evidence tracking, Biological System: | Intact tissue |
| Evidence tracking, Protein Targeting: | Antibody (detection) |
| Evidence tracking, Experiment Assay: | Electron Microscopy |
| Annotator(s): | Frank Koopmans (ORCID:0000-0002-4973-5732) Guus Smit (ORCID:0000-0002-2286-1587) Matthijs Verhage (ORCID:0000-0002-2514-0216) |
| Lab: | Department of Functional Genomics, Department of Molecular and Cellular Neurobiology, Center for Neurogenomics and Cognitive Research, Vrije Universiteit Amsterdam, 1081 HV Amsterdam, The Netherlands |
| Additional literature: | Lipid binding specificity of Rac1 is encoded in the amino acid sequence of the polybasic domain (PBD) of the C-terminal membrane anchor. @ PMID:29967243 |
| SynGO annotation ID: | 5363 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |