| Annotated protein: | Protocadherin 7 (Protocadherin 7a). Gene symbol: PCDH7. Taxonomy: Rattus norvegicus (Rat). Uniprot ID: A6IJE8 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ PCDH7 |
| Ontology domain: | Cellular Component |
| SynGO term: | postsynaptic density (GO:0014069) |
| Synapse type(s): | hippocampus |
| Annotated paper: | Wang Y, et al. "PCDH7 interacts with GluN1 and regulates dendritic spine morphology and synaptic function" Sci Rep. 2020 Jul 2;10(1):10951 PMID:32616769 |
| Figure(s): | Figure 2, 5, S3 |
| Annotation description: | Figure 2: PCDH7 was enriched in PSD biochemical fractions prepared from adult mouse brain lysate. Figure 5, S3: "In PCDH7-expressing neurons, SHANK3 had a punctate expression pattern and was highly enriched in those dilatations and strongly co-localized with PCDH7 (Fig. 5D), suggesting that these dilatations might be synapse containing structures. Furthermore, we performed PCDH7 overexpression experiments in dissociated neuronal cultures so that we could stain for endogenous synaptic proteins. Overexpressed PCDH7 was localized to the dendritic dilatations and was partially colocalized with the presynaptic marker synapsin and postsynaptic marker PSD95 (Supplementary Fig. S3A,B)." |
| Evidence tracking, Biological System: | Cultured neurons |
| Evidence tracking, Protein Targeting: | Over-expression Antibody (detection) |
| Evidence tracking, Experiment Assay: | Confocal Western blot Biochemical fractionation (generic) |
| Annotator(s): | Frank Koopmans (ORCID:0000-0002-4973-5732) Guus Smit (ORCID:0000-0002-2286-1587) Matthijs Verhage (ORCID:0000-0002-2514-0216) |
| Lab: | Department of Functional Genomics, Department of Molecular and Cellular Neurobiology, Center for Neurogenomics and Cognitive Research, Vrije Universiteit Amsterdam, 1081 HV Amsterdam, The Netherlands |
| SynGO annotation ID: | 5349 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |