| Annotated protein: | Probable ubiquitin carboxyl-terminal hydrolase FAF-X (EC 3.4.19.12) (Deubiquitinating enzyme FAF-X) (Fat facets homolog) (Fat facets protein-related, X-linked) (Ubiquitin carboxyl-terminal hydrolase FAM) (Ubiquitin thioesterase FAF-X) (Ubiquitin-specific protease 9, X chromosome) (Ubiquitin-specific-processing protease FAF-X). Gene symbol: USP9X. Taxonomy: Mus musculus (Mouse). Uniprot ID: P70398 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ USP9X |
| Ontology domain: | Biological Process |
| SynGO term: | regulation of postsynapse assembly (GO:0150052) |
| Synapse type(s): | cerebral cortex |
| Annotated paper: | Yoon S, et al. "Usp9X Controls Ankyrin-Repeat Domain Protein Homeostasis during Dendritic Spine Development" Neuron. 2020 Feb 5;105(3):506-521.e7 PMID:31813652 |
| Figure(s): | Figure 3, 6 |
| Annotation description: | Figure 3: Usp9X regulates spine morphology by deubiquitination of Ankyrin-G (ANK3). Figure 6: Absence of Usp9X causes persistent reduction in dendritic spine density and increase of Ankyrin-G (ANK3) ubiquitination and aggregation in mouse cortex. |
| Evidence tracking, Biological System: | Intact tissue |
| Evidence tracking, Protein Targeting: | Genetic transformation (eg; knockout, knockin, mutations) |
| Evidence tracking, Experiment Assay: | Confocal Western blot |
| Annotator(s): | Frank Koopmans (ORCID:0000-0002-4973-5732) Guus Smit (ORCID:0000-0002-2286-1587) Matthijs Verhage (ORCID:0000-0002-2514-0216) |
| Lab: | Department of Functional Genomics, Department of Molecular and Cellular Neurobiology, Center for Neurogenomics and Cognitive Research, Vrije Universiteit Amsterdam, 1081 HV Amsterdam, The Netherlands |
| Additional literature: | "Figure 2. TGF-β-Enhanced Interaction of Ankyrin-G and Usp9X Regulates Spine Morphogenesis" @ PMID:32460012 |
| SynGO annotation ID: | 5343 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |