Annotated protein:Probable ubiquitin carboxyl-terminal hydrolase FAF-X (EC 3.4.19.12) (Deubiquitinating enzyme FAF-X) (Fat facets homolog) (Fat facets protein-related, X-linked) (Ubiquitin carboxyl-terminal hydrolase FAM) (Ubiquitin thioesterase FAF-X) (Ubiquitin-specific protease 9, X chromosome) (Ubiquitin-specific-processing protease FAF-X). Gene symbol: USP9X. Taxonomy: Mus musculus (Mouse). Uniprot ID: P70398
antibody wiki:
SynGO gene info:SynGO data @ USP9X
Ontology domain:Cellular Component
SynGO term:postsynapse (GO:0098794)
Annotated paper:Yoon S, et al. "Usp9X Controls Ankyrin-Repeat Domain Protein Homeostasis during Dendritic Spine Development" Neuron. 2020 Feb 5;105(3):506-521.e7 PMID:31813652
Figure(s):Figure 2
Annotation description:Figuire 2: SIM super-resolution imaging of endogenous AnkG (ankyrin-G, gene ANK3) and Usp9X showed co-localization at/near dendritic spine heads. "Most spines exhibited two or more ankyrin-G nanodomains surrounding Usp9X (Figure 2D)."
Evidence tracking, Biological System:Intact tissue
Evidence tracking, Protein Targeting:Antibody (detection)
Evidence tracking, Experiment Assay:Super resolution
Annotator(s):Frank Koopmans (ORCID:0000-0002-4973-5732)
Guus Smit (ORCID:0000-0002-2286-1587)
Matthijs Verhage (ORCID:0000-0002-2514-0216)
Lab:Department of Functional Genomics, Department of Molecular and Cellular Neurobiology, Center for Neurogenomics and Cognitive Research, Vrije Universiteit Amsterdam, 1081 HV Amsterdam, The Netherlands
SynGO annotation ID:5342
Dataset release (version):20231201
View annotation as GO-CAM model:Gene Ontology