| Annotated protein: | Leucine-rich repeat transmembrane protein FLRT2 (Fibronectin-like domain-containing leucine-rich transmembrane protein 2). Gene symbol: FLRT2. Taxonomy: Rattus norvegicus (Rat). Uniprot ID: D3ZTV3 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ FLRT2 |
| Ontology domain: | Biological Process |
| SynGO term: | regulation of postsynapse assembly (GO:0150052) |
| Synapse type(s): | hippocampus |
| Annotated paper: | Schroeder A, et al. "A Modular Organization of LRR Protein-Mediated Synaptic Adhesion Defines Synapse Identity" Neuron. 2018 Jul 25;99(2):329-344.e7 PMID:29983322 |
| Figure(s): | Figure 5 |
| Annotation description: | "We injected lentiviral vectors into the CA1 region of P0 rat pups and imaged P14 secondary apical CA1 dendrites in SR on a structured illumination microscope followed by analysis of dendritic spine density. FLRT2 KD caused a strong, 47.3% decrease in dendritic spine density compared to dendrites from CA1 neurons infected with control lentivirus (Figures 5A and 5B). ... Spine shape was not detectably altered in any of the KD conditions (Figure S6A)" |
| Evidence tracking, Biological System: | Intact tissue |
| Evidence tracking, Protein Targeting: | RNAi / shRNA |
| Evidence tracking, Experiment Assay: | Confocal |
| Annotator(s): | Frank Koopmans (ORCID:0000-0002-4973-5732) Guus Smit (ORCID:0000-0002-2286-1587) Matthijs Verhage (ORCID:0000-0002-2514-0216) |
| Lab: | Department of Functional Genomics, Department of Molecular and Cellular Neurobiology, Center for Neurogenomics and Cognitive Research, Vrije Universiteit Amsterdam, 1081 HV Amsterdam, The Netherlands |
| SynGO annotation ID: | 5335 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |