| Annotated protein: | Leucine-rich repeat transmembrane protein FLRT2 (Fibronectin-like domain-containing leucine-rich transmembrane protein 2). Gene symbol: FLRT2. Taxonomy: Rattus norvegicus (Rat). Uniprot ID: D3ZTV3 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ FLRT2 |
| Ontology domain: | Cellular Component |
| SynGO term: | integral component of postsynaptic membrane (GO:0099055) |
| Synapse type(s): | hippocampus, glutamatergic |
| Annotated paper: | Schroeder A, et al. "A Modular Organization of LRR Protein-Mediated Synaptic Adhesion Defines Synapse Identity" Neuron. 2018 Jul 25;99(2):329-344.e7 PMID:29983322 |
| Figure(s): | Figure 1, 2 |
| Annotation description: | Figure 1j, 2: confocal imaging of immunofluorescence labeling for FLRT2, Bassoon (BSN) and PSD-95 (DLG4) in hippocampal neurons from rat brain cryosections showed localization was "opposed to the presynaptic marker Bassoon, confirming a postsynaptic localization." Localization to dendritic spines was confirmed at higher magnification (Fig. 2). Based on the known transmembrane topology of this protein, "integral component of ... membrane" term was selected. |
| Evidence tracking, Biological System: | Intact tissue |
| Evidence tracking, Protein Targeting: | Antibody (detection) |
| Evidence tracking, Experiment Assay: | Confocal |
| Annotator(s): | Frank Koopmans (ORCID:0000-0002-4973-5732) Guus Smit (ORCID:0000-0002-2286-1587) Matthijs Verhage (ORCID:0000-0002-2514-0216) |
| Lab: | Department of Functional Genomics, Department of Molecular and Cellular Neurobiology, Center for Neurogenomics and Cognitive Research, Vrije Universiteit Amsterdam, 1081 HV Amsterdam, The Netherlands |
| SynGO annotation ID: | 5332 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |