| Annotated protein: | Sodium channel protein type 2 subunit alpha (Sodium channel protein brain II subunit alpha) (Sodium channel protein type II subunit alpha) (Voltage-gated sodium channel subunit alpha Nav1.2). Gene symbol: SCN2A. Taxonomy: Rattus norvegicus (Rat). Uniprot ID: P04775 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ SCN2A |
| Ontology domain: | Biological Process |
| SynGO term: | voltage-gated ion channel activity involved in regulation of presynaptic membrane potential (GO:0099508) |
| Annotated paper: | James TF, et al. "The Nav1.2 channel is regulated by GSK3" Biochim Biophys Acta. 2015 Apr;1850(4):832-44 PMID:25615535 |
| Figure(s): | Fig.1 |
| Annotation description: | This paper shows that Nav1.2 is a sodium channel. Rat Nav1.2 channels are expressed in HEK cells and characterised using whole cell voltage clamp. rule: NAS_MFCC-BP rationale: Protein has voltage-gated ion channel activity and is localized in teh presynaptic membrane (show with high-resolution technique). The inference to term 'voltage-gated ion channel activity involved in regulation of presynaptic membrane potential (GO:0099508)' is trivial and non-controversial. Pinf_CC: [Q68V27] SyNGO ID 531 (PMID:22528969, EM) |
| Evidence tracking, Biological System: | Non-neuronal tissue |
| Evidence tracking, Protein Targeting: | Over-expression |
| Evidence tracking, Experiment Assay: | Whole-cell patch clamp |
| Non-tracable Author Statement (NAS): | This annotation required some inference over additional information/literature, and is not solely based on observations made in the annotated paper by its original authors. |
| Annotator(s): | Niels Cornelisse (ORCID:0000-0001-9425-2935) Matthijs Verhage (ORCID:0000-0002-2514-0216) |
| Lab: | Department of Functional Genomics, Center for Neurogenomics and Cognitive Research, Vrije Universiteit Amsterdam, 1081 HV Amsterdam, The Netherlands |
| SynGO annotation ID: | 533 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |