| Annotated protein: | Semaphorin-4C (M-Sema F) (Semaphorin-C-like 1) (Sema I) (Semaphorin I). Gene symbol: SEMA4C. Taxonomy: Mus musculus (Mouse). Uniprot ID: Q64151 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ SEMA4C |
| Ontology domain: | Biological Process |
| SynGO term: | regulation of postsynapse assembly (GO:0150052) |
| Synapse type(s): | hippocampus, glutamatergic |
| Annotated paper: | Simonetti M, et al. "The impact of Semaphorin 4C/Plexin-B2 signaling on fear memory via remodeling of neuronal and synaptic morphology" Mol Psychiatry. 2021 Apr;26(4):1376-1398 PMID:31444474 |
| Figure(s): | Figure 6 |
| Annotation description: | "In parallel, we analyzed the effects of Sema4C exposure on dendritic protrusions and observed that Sema4C treatment led to a significant rise in the density of spines in hippocampal neurons (Fig. 6e, f). Pre-incubation with the ROCK inhibitor Y-27632 abolished the Sema4C-mediated increase in spine density (Fig. 6e, f)." |
| Evidence tracking, Biological System: | Cultured neurons |
| Evidence tracking, Protein Targeting: | Over-expression |
| Evidence tracking, Experiment Assay: | Confocal |
| Annotator(s): | Frank Koopmans (ORCID:0000-0002-4973-5732) Guus Smit (ORCID:0000-0002-2286-1587) Matthijs Verhage (ORCID:0000-0002-2514-0216) |
| Lab: | Department of Functional Genomics, Department of Molecular and Cellular Neurobiology, Center for Neurogenomics and Cognitive Research, Vrije Universiteit Amsterdam, 1081 HV Amsterdam, The Netherlands |
| SynGO annotation ID: | 5322 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |