| Annotated protein: | SH3 and multiple ankyrin repeat domains protein 1 (Shank1). Gene symbol: SHANK1. Taxonomy: Mus musculus (Mouse). Uniprot ID: D3YZU1 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ SHANK1 |
| Ontology domain: | Cellular Component |
| SynGO term: | postsynaptic density (GO:0014069) |
| Synapse type(s): | hippocampus, glutamatergic |
| Annotated paper: | Hung AY, et al. "Smaller dendritic spines, weaker synaptic transmission, but enhanced spatial learning in mice lacking Shank1" J Neurosci. 2008 Feb 13;28(7):1697-708 PMID:18272690 |
| Figure(s): | Fig. 2b, Fig. 3a |
| Annotation description: | Fig. 2b Shank1 is present in PSD fractions Literal "By immunoblotting, the Shank1-specific 1356 antibody confirmed the absence of Shank1 protein in the PSD fraction of Shank1 knock-out brains." Fig-3b Shank1 colocalized with PSD-95 |
| Evidence tracking, Biological System: | Cultured neurons |
| Evidence tracking, Protein Targeting: | Antibody (detection) |
| Evidence tracking, Experiment Assay: | Confocal Biochemical fractionation (generic) |
| Annotator(s): | Chiara Verpelli (ORCID:0000-0003-2949-9725) Carlo Sala (ORCID:0000-0003-0662-9523) |
| Lab: | CNR Neuroscience Institute Milan and Dept. of Biotechnology and Translational Medicine, University of Milan, 20129 Milan, Italy |
| Additional literature: | Fig.4 Super resolution imaging shows Shank1 postsynaptic localization @ PMID:21144999 |
| SynGO annotation ID: | 532 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |