| Annotated protein: | Voltage-gated sodium channel alpha subunit Nav1.2. Gene symbol: SCN2A. Taxonomy: Mus musculus (Mouse). Uniprot ID: Q68V27 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ SCN2A |
| Ontology domain: | Cellular Component |
| SynGO term: | integral component of presynaptic membrane (GO:0099056) |
| Synapse type(s): | cerebellum, glutamatergic |
| Annotated paper: | Martinez-Hernandez J, et al. "Polarised localisation of the voltage-gated sodium channel Na(v)1.2 in cerebellar granule cells" Cerebellum. 2013 Feb;12(1):16-26 PMID:22528969 |
| Figure(s): | Fig. 5h-i |
| Annotation description: | Sodium (ion) channel, located in the pre-synapse. Contributes to excitability of the synapse. 15/5/2017 Pim - Authors state: "Nav1.2 immunoparticles were always localised to the extrasynaptic plasma membrane." Localization to AZ membrane is therefore not in question. |
| Evidence tracking, Biological System: | Intact tissue |
| Evidence tracking, Protein Targeting: | Antibody (detection) |
| Evidence tracking, Experiment Assay: | Electron Microscopy |
| Annotator(s): | Niels Cornelisse (ORCID:0000-0001-9425-2935) Matthijs Verhage (ORCID:0000-0002-2514-0216) |
| Lab: | Department of Functional Genomics, Center for Neurogenomics and Cognitive Research, Vrije Universiteit Amsterdam, 1081 HV Amsterdam, The Netherlands |
| SynGO annotation ID: | 531 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |