| Annotated protein: | Fibroblast growth factor 22 (FGF-22). Gene symbol: FGF22. Taxonomy: Mus musculus (Mouse). Uniprot ID: Q9ESS2 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ FGF22 |
| Ontology domain: | Cellular Component |
| SynGO term: | postsynapse (GO:0098794) |
| Synapse type(s): | hippocampus, glutamatergic |
| Annotated paper: | Terauchi A, et al. "Distinct FGFs promote differentiation of excitatory and inhibitory synapses" Nature. 2010 Jun 10;465(7299):783-7 PMID:20505669 |
| Figure(s): | Figure 3 |
| Annotation description: | Figure 3e-j: immunofluorescence imaging of FGF22 in cultured hippocampal neurons showed co-localization with excitatory postsynapse marker protein PSD95 (DLG4). Same results for both overexpressed FGF22-EGFP and endogenous FGF22. FGF22 did not colocalize with inhibitory synapse marker proteins. |
| Evidence tracking, Biological System: | Cultured neurons |
| Evidence tracking, Protein Targeting: | Over-expression Antibody (detection) |
| Evidence tracking, Experiment Assay: | Confocal |
| Annotator(s): | Frank Koopmans (ORCID:0000-0002-4973-5732) Guus Smit (ORCID:0000-0002-2286-1587) Matthijs Verhage (ORCID:0000-0002-2514-0216) |
| Lab: | Department of Functional Genomics, Department of Molecular and Cellular Neurobiology, Center for Neurogenomics and Cognitive Research, Vrije Universiteit Amsterdam, 1081 HV Amsterdam, The Netherlands |
| SynGO annotation ID: | 5307 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |