| Annotated protein: | Fibroblast growth factor 7 (FGF-7) (Heparin-binding growth factor 7) (HBGF-7) (Keratinocyte growth factor) (KGF). Gene symbol: FGF7. Taxonomy: Mus musculus (Mouse). Uniprot ID: P36363 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ FGF7 |
| Ontology domain: | Biological Process |
| SynGO term: | regulation of synapse maturation (GO:0090128) |
| Synapse type(s): | hippocampus, GABAergic |
| Annotated paper: | Terauchi A, et al. "Distinct FGFs promote differentiation of excitatory and inhibitory synapses" Nature. 2010 Jun 10;465(7299):783-7 PMID:20505669 |
| Figure(s): | Figure 2, 3 |
| Annotation description: | Figure 2: FGF7 knockout mice have impaired synapse maturation/differentiation. Figure 3a-d: "Overexpression of FGF22 and FGF7 in cultured hippocampal neurons leads to an increase in the clustering of VGLUT1 and VGAT puncta, respectively, on the FGF-expressing neuron (Fig. 3a). This suggests that FGF22 and FGF7 specifically promote differentiation of glutamatergic and GABAergic presynaptic terminals, respectively, as target-derived molecules." Figure 3e-j: immunofluorescence imaging of FGF7 in cultured hippocampal neurons showed co-localization with inhibitory postsynapse marker protein Gephyrin (GPHN). Same results for both overexpressed FGF7-DsRed and endogenous FGF7. FGF7 did not colocalize with excitatory synapse marker proteins. |
| Evidence tracking, Biological System: | Cultured neurons |
| Evidence tracking, Protein Targeting: | Genetic transformation (eg; knockout, knockin, mutations) Over-expression Antibody (detection) |
| Evidence tracking, Experiment Assay: | Electron Microscopy Confocal |
| Annotator(s): | Frank Koopmans (ORCID:0000-0002-4973-5732) Guus Smit (ORCID:0000-0002-2286-1587) Matthijs Verhage (ORCID:0000-0002-2514-0216) |
| Lab: | Department of Functional Genomics, Department of Molecular and Cellular Neurobiology, Center for Neurogenomics and Cognitive Research, Vrije Universiteit Amsterdam, 1081 HV Amsterdam, The Netherlands |
| SynGO annotation ID: | 5305 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |