| Annotated protein: | Fibroblast growth factor 22 (FGF-22). Gene symbol: FGF22. Taxonomy: Mus musculus (Mouse). Uniprot ID: Q9ESS2 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ FGF22 |
| Ontology domain: | Biological Process |
| SynGO term: | trans-synaptic signaling (GO:0099537) |
| Synapse type(s): | hippocampus, glutamatergic |
| Annotated paper: | Hu HT, et al. "Postsynaptic SDC2 induces transsynaptic signaling via FGF22 for bidirectional synaptic formation" Sci Rep. 2016 Sep 15;6:33592 PMID:27627962 |
| Figure(s): | Figure 4, 7 |
| Annotation description: | Figure 3, 5, 6: FGF22 coimmunoprecipitated with SDC2 in neuro2A cells and overexpressed FGF22 was localized to dendritic spines in hippocampal neurons (localization seems most concentrated at the spine tip). Postsynaptic localization was strongly reduced upon SDC2 shRNA knockdown. Figure 4: FGF22 interacts with SDC2 via heparan sulfate conjugates and contributes to SDC2-induced presynaptic differentiation. Figure 7: FGF22 triggers the filepodia-to-spine transition induced by SDC2 in cultured rat hippocampal neurons. Because the synaptic maturation pathway that involves postsynaptic SDC affects presynaptic maturation as well (Fig. 5), authors infer some retrograde trans-synaptic signaling must be involved and this role is probably fulfilled by FDF22 (Fig. 8). Figure 8: authors propose a model where FGF22 is attached to SDC2 (which is at the PSD membrane) and released from there to act on presynaptic receptors. "Thus, by combining the retrograde signal of FGF22 and anterograde neurotransmission, the positive transsynaptic feedback loop established by the SDC2-associated complex coordinates the differentiation of both pre- and post-synaptic termini (Fig. 8), explaining why postsynaptic expression of SDC2 triggers both post- and pre-synaptic differentiation." |
| Evidence tracking, Biological System: | Cultured neurons |
| Evidence tracking, Protein Targeting: | Over-expression |
| Evidence tracking, Experiment Assay: | Confocal |
| Annotator(s): | Frank Koopmans (ORCID:0000-0002-4973-5732) Guus Smit (ORCID:0000-0002-2286-1587) Matthijs Verhage (ORCID:0000-0002-2514-0216) |
| Lab: | Department of Functional Genomics, Department of Molecular and Cellular Neurobiology, Center for Neurogenomics and Cognitive Research, Vrije Universiteit Amsterdam, 1081 HV Amsterdam, The Netherlands |
| Additional literature: | synaptic localization of FGF22 and functional studies using knockout mice @ PMID:20505669 |
| SynGO annotation ID: | 5303 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |