| Annotated protein: | SH3 and multiple ankyrin repeat domains protein 3 (Shank3) (Proline-rich synapse-associated protein 2) (ProSAP2) (SPANK-2). Gene symbol: SHANK3. Taxonomy: Rattus norvegicus (Rat). Uniprot ID: Q9JLU4 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ SHANK3 |
| Ontology domain: | Cellular Component |
| SynGO term: | postsynaptic density (GO:0014069) |
| Synapse type(s): | hippocampus, glutamatergic |
| Annotated paper: | MacGillavry HD, et al. "Nanoscale scaffolding domains within the postsynaptic density concentrate synaptic AMPA receptors" Neuron. 2013 May 22;78(4):615-22 PMID:23719161 |
| Figure(s): | Fig. 3 |
| Annotation description: | Fig. 3 Shank3 clusters are present in the PSD |
| Evidence tracking, Biological System: | Cultured neurons |
| Evidence tracking, Protein Targeting: | Over-expression |
| Evidence tracking, Experiment Assay: | Super resolution |
| Annotator(s): | Chiara Verpelli (ORCID:0000-0003-2949-9725) Carlo Sala (ORCID:0000-0003-0662-9523) |
| Lab: | CNR Neuroscience Institute Milan and Dept. of Biotechnology and Translational Medicine, University of Milan, 20129 Milan, Italy |
| Additional literature: | Fig. 9 Shank 3-immunogold labeling shows that Shank3 is localized at synapses. @ PMID:15894489 |
| SynGO annotation ID: | 530 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |