| Annotated protein: | Ras-related C3 botulinum toxin substrate 3 (EC 3.6.5.2) (p21-Rac3). Gene symbol: RAC3. Taxonomy: Mus musculus (Mouse). Uniprot ID: P60764 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ RAC3 |
| Ontology domain: | Cellular Component |
| SynGO term: | postsynapse (GO:0098794) |
| Synapse type(s): | hippocampus, glutamatergic |
| Annotated paper: | Pennucci R, et al. "Rac1 and Rac3 GTPases differently influence the morphological maturation of dendritic spines in hippocampal neurons" PLoS One. 2019 Aug 1;14(8):e0220496 PMID:31369617 |
| Figure(s): | Figure 3 |
| Annotation description: | Figure 3: overexpression of GFP-Rac3 showed localization to dendritic shaft and spines (co-localizatoin with endogenous Homer) in 4DIV hippocampal neurons. Figure 4: double knockout of Rac1 and Rac3 leads to severely impaired postsynapse formation in 4DIV hippocampal neurons, which could be rescued by overexpression of either GFP-Rac3 or GFP-Rac1. |
| Evidence tracking, Biological System: | Cultured neurons |
| Evidence tracking, Protein Targeting: | Over-expression |
| Evidence tracking, Experiment Assay: | Confocal |
| Annotator(s): | Frank Koopmans (ORCID:0000-0002-4973-5732) Guus Smit (ORCID:0000-0002-2286-1587) Matthijs Verhage (ORCID:0000-0002-2514-0216) |
| Lab: | Department of Functional Genomics, Department of Molecular and Cellular Neurobiology, Center for Neurogenomics and Cognitive Research, Vrije Universiteit Amsterdam, 1081 HV Amsterdam, The Netherlands |
| SynGO annotation ID: | 5296 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |