| Annotated protein: | Vesicle-associated membrane protein-associated protein B (VAMP-B) (VAMP-associated protein B) (VAP-B). Gene symbol: VAPB. Taxonomy: Rattus norvegicus (Rat). Uniprot ID: Q9Z269 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ VAPB |
| Ontology domain: | Cellular Component |
| SynGO term: | presynaptic ER |
| Synapse type(s): | hippocampus, glutamatergic |
| Annotated paper: | Gomez-Suaga P, et al. "The VAPB-PTPIP51 endoplasmic reticulum-mitochondria tethering proteins are present in neuronal synapses and regulate synaptic activity" Acta Neuropathol Commun. 2019 Mar 6;7(1):35 PMID:30841933 |
| Figure(s): | Figure 1 |
| Annotation description: | vesicle-associated membrane protein-associated protein B (VAPB) is a known ER protein (PMID:26899735). Figure 1: SIM super-resolution microscopy of cultured rat hippocampal neurons showed VAPB localized to the presynaptic compartment (identified by immunostaining for axons with phosphorylated NFH and synaptophysin). Figure 1e: VAPB and PTPIP51 are present in synaptoneurosome biochemical fractions prepared from rat brain. |
| Evidence tracking, Biological System: | Cultured neurons Intact tissue |
| Evidence tracking, Protein Targeting: | Antibody (detection) |
| Evidence tracking, Experiment Assay: | Western blot Biochemical fractionation (generic) Super resolution |
| Annotator(s): | Frank Koopmans (ORCID:0000-0002-4973-5732) Guus Smit (ORCID:0000-0002-2286-1587) Matthijs Verhage (ORCID:0000-0002-2514-0216) |
| Lab: | Department of Functional Genomics, Department of Molecular and Cellular Neurobiology, Center for Neurogenomics and Cognitive Research, Vrije Universiteit Amsterdam, 1081 HV Amsterdam, The Netherlands |
| SynGO annotation ID: | 5292 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |