| Annotated protein: | SLIT-ROBO Rho GTPase-activating protein 3 (srGAP3) (Mental disorder-associated GAP) (Rho GTPase-activating protein 14) (WAVE-associated Rac GTPase-activating protein) (WRP). Gene symbol: SRGAP3. Taxonomy: Homo sapiens (Human). Uniprot ID: O43295 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ SRGAP3 |
| Ontology domain: | Cellular Component |
| SynGO term: | postsynapse (GO:0098794) |
| Synapse type(s): | hippocampus |
| Annotated paper: | Hlushchenko I, et al. "ASD-Associated De Novo Mutations in Five Actin Regulators Show Both Shared and Distinct Defects in Dendritic Spines and Inhibitory Synapses in Cultured Hippocampal Neurons" Front Cell Neurosci. 2018 Aug 3;12:217 PMID:30123108 |
| Figure(s): | Figure 13 |
| Annotation description: | Figure 13b, c: immunofluorescence imaging of cultured hippocampal neurons showed overexpressed SRGAP3 was enriched in dendritic spines at a ratio of 1.32 compared to diffuse GFP with a ratio of 0.99. |
| Evidence tracking, Biological System: | Cultured neurons |
| Evidence tracking, Protein Targeting: | Over-expression |
| Evidence tracking, Experiment Assay: | Confocal |
| Annotator(s): | Frank Koopmans (ORCID:0000-0002-4973-5732) Guus Smit (ORCID:0000-0002-2286-1587) Matthijs Verhage (ORCID:0000-0002-2514-0216) |
| Lab: | Department of Functional Genomics, Department of Molecular and Cellular Neurobiology, Center for Neurogenomics and Cognitive Research, Vrije Universiteit Amsterdam, 1081 HV Amsterdam, The Netherlands |
| SynGO annotation ID: | 5288 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |