Annotated protein:Unconventional myosin-IXb (Unconventional myosin-9b). Gene symbol: MYO9B. Taxonomy: Homo sapiens (Human). Uniprot ID: Q13459
antibody wiki:
SynGO gene info:SynGO data @ MYO9B
Ontology domain:Cellular Component
SynGO term:postsynaptic actin cytoskeleton (GO:0098871)
Synapse type(s):hippocampus
Annotated paper:Hlushchenko I, et al. "ASD-Associated De Novo Mutations in Five Actin Regulators Show Both Shared and Distinct Defects in Dendritic Spines and Inhibitory Synapses in Cultured Hippocampal Neurons" Front Cell Neurosci. 2018 Aug 3;12:217 PMID:30123108
Figure(s):Figure 9
Annotation description:Figure 9a,b: immunofluorescence imaging of cultured hippocampal neurons showed overexpressed myosin IXb (MYO9B) showed enrichment in spine heads 1.6 times that of mCherry.
Evidence tracking, Biological System:Cultured neurons
Evidence tracking, Protein Targeting:Over-expression
Evidence tracking, Experiment Assay:Confocal
Annotator(s):Frank Koopmans (ORCID:0000-0002-4973-5732)
Guus Smit (ORCID:0000-0002-2286-1587)
Matthijs Verhage (ORCID:0000-0002-2514-0216)
Lab:Department of Functional Genomics, Department of Molecular and Cellular Neurobiology, Center for Neurogenomics and Cognitive Research, Vrije Universiteit Amsterdam, 1081 HV Amsterdam, The Netherlands
SynGO annotation ID:5286
Dataset release (version):20231201
View annotation as GO-CAM model:Gene Ontology